The author argues that self-interested m-Cooperate strategy is unstable and easily afflicted by chance events of for example one m-Cooperator turning to Defect. Why couldn't the strategies also adapt to become stochastic and tolerant to chance events? The author admits himself that this doesn't exclude the possible existence of strategies immune to chance events. Nevertheless, such partial results are commonly used as arguments for inefficiency of self-interest and for the necessity of exogenous factors such as institutions.
The other argument using implausibility of self-interested cooperation in large groups instead of in a dyadic setting is also debatable. Individuals in large groups are not isolated from each other. There is the social network structure connecting group members and graph theory has shown that it is possible to connect most individuals in the world with one another within a very small number of links (social networks theory, 6 degrees of separation). This makes reciprocal actions not unlikely, and reciprocal altruism not unlikely, if the individuals realize this connectivity.
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